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imrab rabies vaccine ingredients

Newcastle disease virus (NDV), an avian paramyxovirus, has shown promise as a vaccine vector for mammals. Rabies - No rabies vaccine is licensed for goats in the US. Vaccine 2018;36:2604-2611. gelatin . Effective, safe, and affordable rabies vaccines are still being sought. Safety and immunogenicity of this product have been demonstrated by vaccination and challenge tests in susceptible animals. For example, many vaccines contain salts based on sodium and potassium (see the section on 'Acidity regulators'), which are essential for life. Imrab 3 has been approved for ferrets and, in some areas, pet skunks . IMRAB rabies vaccines. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. However, the role of aluminum is unclear because not all adjuvants used in the vaccines that have been associated with sarcoma formation have contained aluminum. Imovax Rabies vaccine should be given to a pregnant woman only if potential benefits outweigh potential risks. If there is substantial risk of exposure to rabies, pre-exposure prophylaxis may also be indicated during pregnancy. Do not freeze. Return to top. The virus is grown in a stable cell line, inactivated, and mixed with a safe and potent adjuvant. Highly purified, inactivated virus used in vaccine production. Do not pass it on to others. Vaccine ingredients can look unfamiliar. However, there has been one long term study testing the Merial sheep rabies vaccine (Imrab®) on goats. PUREVAX, for the protection of felines. hydrolyzed porcine gelatin. Related Pages. They can be used to prevent rabies before, and for a period of time after, exposure to the rabies virus, which is commonly caused by a dog bite or a bat bite. Other products for companion animals include these world-class brands: Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Wild animals like bats, raccoons, skunks, and foxes are the most common source of human rabies infection in the United States. Rabies vaccine can prevent rabies. A transient local reaction may occur at the injection site following subcutaneous administration. This is called post-exposure prophylaxis. RECOMBITEK vaccines for Dogs. IMRAB has been trusted by veterinarians for more than 30 years to protect hundreds of millions of animals from rabies. 2; View details Order now. Select one or more newsletters to continue. Imrab is an example of a veterinary rabies vaccine containing the Pasteur strain of killed rabies virus. Home; Vaccines; Ingredients; Ingredients. Check for outbreak alerts in your area at: Outbreak-Alert.com Imrab-3 is a rabies vaccine that is recommended for the vaccination of horses against rabies. Manufactured By MERIAL INC., Athens, GA 30601 USA, Distributed In Canada By MERIAL CANADA, INC., Baie d’Urfé, Qc, H9X 3V1, Copyright © 2020 Animalytix LLC. Content source: National Center for Immunization and Respiratory Diseases. Do not use chemicals to sterilize syringes and needles. 1; IMRAB 3 is approved for use in 6 species: dogs, cats, ferrets, horses, cattle and sheep. Updated: 2020-10-21. If there is substantial risk of exposure to rabies, pre-exposure prophylaxis may also be indicated during pregnancy. The virus is harvested from infected human diploid cells, MRC-5 strain, concentrated by ultrafiltration and is inactivated by beta-propiolactone. DESCRIPTION: IMRAB® 3 TF contains the same virus strain that is used in the Pasteur Merieux Connaught human vaccine. Rabies virus vaccine is an exception. The virus is grown in a stable cell line, inactivated, and mixed with a safe and potent adjuvant. Rabies is a rare disease in the United States, but it’s almost always deadly. Additional doses should be administered on days 3, 7, and 14 after the first vaccination. In addition to the live, attenuated or inactive virus, pathogen or toxoid, the Rabies (Imovax) vaccine contains the following ingredients: human albumin; neomycin sulfate; phenol red indicator; MRC-5 human diploid cells; betapropriolactone; Source: … home Parents. Humans get rabies when they are bitten or scratched by infected animals. Updated: 2020-10-21. At Merial, we are proud to offer the quality vaccines that support your patients' good health, including: IMRAB ®, world leader in rabies prevention 1. IMRAB Rabies Vaccines IMRAB is the trusted rabies prevention with over 35 years of proven safety 1; IMRAB 3 is the only rabies vaccine approved for use in 6 species 2; IMRAB is available in both a 1- and 3-year DOI formulation Side Effects. Previous . Killed Virus. Pack Type Vial. Resources for your clinic. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Also listed are substances used in the manufacturing process. IMRAB is a registered trademark of MERIAL. This is why we need to review about rabies vaccine as prevention and control option of it. Contains gentamicin as a preservative. Vaccine Ingredients What vaccines are made of. February 28, 2019 admin 0. Rabies is mainly a disease of animals. These rabies vaccine side effects usually disappear within a few days. Rabies 3 Year TF. Case Qty 50. The first dose of the four-dose course should be administered as soon as possible after exposure. Imovax Rabies vaccine should be given to a pregnant woman only if potential benefits outweigh potential risks. This medicinal product was prescribed for you only. At present there is no evidence that persons are at increased risk if they have egg hypersensitivities that are not anaphylactic or anaphylactoid in nature. Animal Species: Ferret,Canine,Feline: View Product Compilation Summary. February 28, 2019 admin Ingredients 0. E. coli. Rabies vaccine is given to persons who have been exposed (eg, by a bite, scratch, or lick) to an animal that is known, or thought, to have rabies. Imrab-3 DOSAGE: Aseptically inject 1 mL (1 dose) subcutaneously or intramuscularly into healthy cats or dogs; 2 mL into healthy sheep, cattle, and horses. Do not use chemicals to sterilize syringes and needles. IMRAB offers many unique advantages to veterinarians — and the animals in their care: IMRAB has been widely used for more than 20 years — with millions of animals protected against rabies. Vaccine Information 2020 Schedules ACIP Recs List of Components/Ingredients Exemptions IOM Reports Legislation Manufacturer Links Package Inserts Breastfeeding & Pregnancy Religion Reporting AEs (off-site link) Thimerosal Table … If a dog, after having received only 1 dose of rabies vaccine, is subsequently exposed to virulent rabies virus, exposure to the virulent virus then serves as … Treatment may include antihistamines, anti-inflammatories, and/or epinephrine. 11. Like other inactivated vaccines, the initial dose of a rabies vaccine serves as the “priming” dose. Best of all, you can download these lifestyle sheets, brochures and maps, and print and share them in your clinic. Rabies vaccine may also be given ahead of time to persons who have a high risk of getting infected with rabies virus. Vaccine Ingredients. 11. Vaccine Ingredients What vaccines are made of. PUREVAX feline vaccines help protect cats against a number of diseases, including rabies, feline leukemia virus (FeLV), panleukopenia, and pathogens that commonly cause respiratory disease in cats. More information about arginine in vaccines coming soon. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. If you have any further questions, ask your doctor, pharmacist or nurse. Includes vaccines that helps protect against rhinotracheitis virus, calicivirus, panleukopenia virus, Chlamydophila felis, Rabies virus, and leukemia virus (FeLV). The virus is grown in a stable cell line, inactivated, and mixed with a safe and potent adjuvant. Case Qty 50. Rabies vaccine info for healthcare professionals: vaccine recommendations, about rabies vaccine, storage and handling, administering vaccine, references and resources Fortunately, reactions to vaccines are very uncommon in cats. This list of vaccine ingredients indicates the culture media used in the production of common vaccines and the excipients they contain, as published by the United States Centers for Disease Control and Prevention and Food and Drug Administration.Vaccine ingredients and production in other nations are substantially the same. Safety and immunogenicity of this product have been demonstrated by vaccination and challenge tests in susceptible animals. The first dose of the four-dose course should be administered as soon as possible after exposure. Human rabies is rare in the United States. • The only rabies vaccine approved for use in six species5 Related Pages. Drug information provided by: IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. RECOMBITEK vaccines for Dogs. We comply with the HONcode standard for trustworthy health information -, Direction and dosage information for IMRAB 3 TF. Every year, thousands of people around the world die from rabies. IMRAB rabies vaccines. In rare instances, administration of vaccines may cause lethargy, fever, and inflammatory or hypersensitivity types of reactions. This product does not contain thimerosal. Revaccinate cattle and horses annually and sheep one year after the first vaccination, then every 3 years. - Use killed vaccine licensed for sheep; Imrab® favored. Every year, thousands of people around the world die from rabies. Unit of Measure 10 Dose. Fort Dodge makes a Thimerosol-free rabies vaccine called RABVAC 3 TF. Why Vaccinate plus icon. Revaccinate ferrets annually. The good news is that this disease is preventable with the rabies vaccine. The rabies vaccine is given to people who are at higher risk of coming in contact with rabies — like veterinarians. The authors describe the safety aspects of three trials comparing a CpG-ODN adjuvanted hepatitis B vaccine with an aluminum-adjuvanted hepatitis B vaccine in more than 13,000 adult subjects. More information about galactose in vaccines coming soon. Use these valuable materials to stay sharp on topics like feline leukemia and canine rabies. Intradermal vaccination has been shown to be as safe and immunogenic as intramuscular vaccination, yet requires less vaccine, for both pre- and post-exposure prophylaxis, leading to lower direct costs. Revaccinate ferrets, cattle, and horses annually; cats, dogs, and sheep 1 year after first vaccination, then every 3 years. IMRAB, world leader in rabies prevention1 IMRAB offers many unique advantages to veterinarians — and the animals in their care: IMRAB 3 is indicated for use in six species (dogs, cats, ferrets, horses, cattle, and sheep), so clinics only need to stock a single rabies vaccine Three-year duration of immunity in dogs, cats, and sheep2 One-year duration of immunity in horses, Do not vaccinate food producing animals within 21 days prior to slaughter. Many thanks to Dr. Pasteur! Rabies vaccine is used in two ways. Material Name: Rabies Vaccine, Killed Virus Eye Irritation Rabbit Mild Rat Para-periosteal LD50 150 mg/kg Gentamicin Merthiolate (as mercury) Eye Irritation Rabbit Non-irritating Gentamicin Version: 2.0 Page 5 of 8 Rat Oral LD50 6600 mg/kg Rat Oral LD50 75 mg/kg reconstituted vaccine contains ≤12 mg polygeline (processed bovine gelatin), ≤0.3 mg human serum albumin, 1 mg potassium glutamate, and 0.3 mg sodium EDTA. Measles vaccines are made using what’s called an attenuated virus.That means it’s been weakened in the lab. Rotavirus (RotaTeq) February 28, 2019 admin 0. To help protect dogs from rabies. Hypersensitivity. When they do happen, they include slight fever, lethargy, decreased appetite and a localized swelling at the vaccine site. Page last reviewed: August 5, 2019. In fact, side effects of rabies vaccines in cats are very rare. More Info; Compare; ON PROMOTION; Login {{promo.PromoName}} {{promo.PromoText}} {{promo.StartDate | date : 'MM/dd/yyyy'}} - {{promo.EndDate | date : 'MM/dd/yyyy'}} Nov- 2020 Oct- 2020 Sep- 2020 Aug- 2020 Jul- 2020 Jun- 2020 … A regimen of four 1-mL doses of HDCV or PCEC vaccines should be administered intramuscularly to previously unvaccinated persons. Treatment may include antihistamines, anti-inflammatories, and/or epinephrine. February 28, 2019 admin 0. Supplied By: Merial (72223) SKU 039883. Pack Type Vial. Disease prevention can make or break a flock’s performance. A note on vaccine safety Vaccines go through many years of safety and effectiveness testing. DESCRIPTION. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Rabies Immune Globulin (Human), Imogam® Rabies - HT (rabies immune globulin (human)) , is indicated for individuals suspected of exposure to rabies, particularly severe exposure, with one exception: persons who have been previously immunized with HDCV Rabies Vaccine in a pre-exposure or postexposure treatment series should receive only vaccine. INDICATIONS: IMRAB® 3 TF is recommended for the vaccination of healthy cats, dogs, and ferrets 12 weeks of age and older for prevention of disease due to rabies virus. Education is the first step in preventing disease in pets. (11) Post-exposure. Post-exposure. DOSAGE: Aseptically inject 1 mL (1 dose) subcutaneously or intramuscularly into healthy cats or dogs; 2 mL into healthy sheep, cattle, and horses. Rabies Vaccine. IMRAB ® from Merial is the world’s leading rabies vaccine. Systemic adverse reactions, including shock, may occur if the rabies vaccine is accidentally administered intravascularly. However, it is important to remember that many of the substances used in vaccines are found naturally in the body. Inject 1 mL subcutaneously into healthy ferrets. Company: Merial Rabies Vaccine. Intradermal immunization using cell-culture-based rabies vaccines is an acceptable alternative to standard intramuscular administration. A transient local reaction may occur at the injection site following subcutaneous administration. There is also a 1 year version, IMRAB 1 TF. - Only a veterinarian can give rabies vaccine in New York - be sure vaccine brand and serial number are recorded. Additional doses should be administered on days 3, 7, and 14 after the first vaccination. IMRAB is a descendent of the first rabies vaccine that Louis Pasteur introduced to the world in the 1884. Rabies Vaccine. 11. DESCRIPTION: IMRAB® 3 contains the same virus strain that is used in the Pasteur Merieux Connaught human vaccine. More information about gelatin in vaccines coming soon. Reliable Vaccination Begins with a Reliable Vaccine. In this Special Feature article, we explore the various components that go into modern vaccines and discuss the purpose of these ingredients. human embryonic lung cell cultures . Vaccine Ingredients. IMRAB offers many unique advantages to veterinarians — and the animals in their care: IMRAB has been widely used for more than 20 years — with millions of animals protected against rabies. Every effort has been made to ensure the accuracy of the IMRAB 3 information published above. Revaccinate 1 year later, then every 3 years. Killed Virus. DOSAGE: Aseptically inject 1 mL (1 dose) subcutaneously or intramuscularly into healthy cats or dogs. RECOMBITEK vaccines for Dogs. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Includes vaccines that helps protect against rhinotracheitis virus, calicivirus, panleukopenia virus, Chlamydophila felis, Rabies virus, and ... IMRAB has been trusted by veterinarians for more than 35 years to protect hundreds of millions of animals from rabies. Some reports suggest that in cats, the administration of certain veterinary biologicals may induce the development of injection site fibrosarcomas. In 2018, Boehringer Ingelheim donated 75,000 doses of rabies vaccine to the Global Alliance for Rabies Control (GARC) in recognition of World Rabies Day on September 28. In addition, initial reports focused on vaccine adjuvants (assisting ingredients) containing aluminum as a potential cause of the sarcoma. Next. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Shake well before using. More Info; Compare; ON PROMOTION; Login {{promo.PromoName}} {{promo.PromoText}} {{promo.StartDate | date : 'MM/dd/yyyy'}} - {{promo.EndDate | date : 'MM/dd/yyyy'}} Nov- 2020 Oct- 2020 Sep- 2020 Aug- 2020 Jul- 2020 Jun- 2020 … However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. Merial is a world-leading, innovation-driven animal health company providing a comprehensive range of products to enhance the well being of animals. Imrab Vaccine - IMRAB® Large Animal is a killed virus rabies vaccine for use in cattle, sheep and horses 3 months of age or older. galactose . Potomavac + Imrab by Merial Indication: For vaccination of healthy horses 3 months of age and older against Potomac Horse Fever and Rabies PHV - Potomac Horse Fever; RAB - Rabies Virus; Status: Killed Virus Dose: Inject 1 ml dose into the muscle, repeat 3 to 4 weeks later, then annually thereafter. IMRAB is a registered trademark of MERIAL. Home; Vaccines; Ingredients; arginine. Optimised safety profile with adjuvant-free protection for all components; Powerful immune response without adjuvant, thanks to its innovative canarypox technology for FeLV and rabies; PUREVAX vaccines for Cats. Although not all of these side effects may occur, if they do occur they may need medical attention. Boehringer Ingelheim Vetmedica animal health website. The rabies vaccine is a vaccine used to prevent rabies. The good news is that this disease is preventable with the rabies vaccine. Protects against rabies For use in healthy cattle, horses and sheep Killed virus vaccine Available in 10 or 25 doses Merial makes a Thimerosol-free rabies vaccine called IMRAB 3 TF (the 3 designates a 3-year vaccine, and TF stands for “Thimersol-free”). In addition to the live, attenuated or inactive virus, pathogen or toxoid, the Rabies (RabAvert) vaccine contains the following ingredients: chicken fibroblasts; β-propiolactone; polygeline (processed bovine gelatin) human serum albumin; bovine serum; potassium glutamate; sodium EDTA; ovalbumin neomycin; chlortetracycline; amphotericin B IMRAB ® from Merial is the world’s leading rabies vaccine. INDICATIONS. The virus is grown in a stable cell line, inactivated, and mixed with a safe and potent adjuvant. Agent(s): Rabies Virus: Trade Name(s): Imrab 3 TF: Distributor(s): No distributor specified . You may need to read it again. Small quantities of Supplied By: Merial (72223) SKU 039883. It’s grown in cultures of chick embryos — basically, unhatched live eggs. In addition to the live, attenuated or inactive virus, pathogen or toxoid, the Varicella (Varivax) Frozen vaccine contains the following ingredients: human embryonic lung cell cultures; guinea pig cell cultures; human diploid cell cultures (WI-38) human diploid cell cultures (MRC-5) sucrose; hydrolyzed gelatin; sodium chloride Anyone who has been bitten by an animal suspected to have rabies, or who otherwise may have been exposed to rabies, should clean the wound and see a health care provider immediately regardless of vaccination status. Simultaneous Vaccination Safety of Ingredients Autism Spectrum Disorders Febrile Seizures Hypersensitivity Reactions More Vaccine Safety Topics. Home; Vaccines; Ingredients; Vaccines. Here, we generated a recombinant avirulent NDV La Sota strain expressing the rabies virus glycoprotein (RVG) and evaluated its potential to serve as a vaccine against rabies. Rabies vaccine can prevent rabies if given to a person after they have had an exposure. • Highly purified, inactivated virus antigen1– no risk of reversion to virulence • Over 30 years of safe and effective use1 • Uses the original Pasteur strain (NIH PV-11) – the same virus strain used in human rabies vaccine Proven convenience. Every effort has been made to ensure the accuracy of the IMRAB 3 TF information published above. Vaccine Ingredients. Rabies is a rare disease in the United States, but it’s almost always deadly. Package contents: One 1 ml vial. Do not freeze. Rabies Vaccine, Killed Virus . Vaccine Ingredients. INDICATIONS: IMRAB® 3 is recommended for the vaccination of healthy cats, dogs, sheep, cattle, horses, and ferrets 12 weeks of age and older for prevention of disease due to rabies virus. Doses are usually given by injection into the skin or muscle. Check for outbreak alerts in your area at: Outbreak-Alert.com Equine POTOMAVAC ® + IMRAB ® is a liquid suspension of inactivated rabies virus propagated in a stable cell line, combined with an inactivated suspension of Ehrlichia risticii.Safety and efficacy of this product have been demonstrated in controlled vaccination challenge tests and thorough field evaluations. Description. Inject 1 mL (1 dose) subcutaneously in healthy ferrets. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. RECOMBITEK. Today’s vaccines use only the ingredients they need to be safe and effective. Some reports suggest that in cats, the administration of certain veterinary biologicals may induce the development of injection site fibrosarcomas. Search for: List of Vaccines. Several different types of Imrab exist, including Imrab, Imrab 3, and Imrab Large Animal. RABIES VACCINE, INACTIVATED Read all of this leaflet carefully before you start using this medicine because it contains important information for you. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. Select one or more newsletters to continue. Shake well before using. Healthy broilers reach heavier weights, and healthy layers produce more eggs, effecting a positive impact on your complexes. IMRAB Plus Large Animal Rabies Vaccine, 20mL, Distributor Ship. Contains gentamicin as a preservative. The rabies vaccine is given to people who are at higher risk of coming in contact with rabies — like veterinarians. PUREVAX vaccines are the only complete line of nonadjuvanted feline vaccines available. Highly purified, inactivated virus used in vaccine production. Manufactured By MERIAL, INC., Athens, GA 30601 USA, Distributed in Canada By MERIAL CANADA, INC., Baie d’Urfé, Qc, H9X 3V1, Copyright © 2020 Animalytix LLC. PUREVAX ®. The Food and Drug Administration (FDA) looks at the results of these tests to decide whether to license the vaccine for use in the United States. There are a number of rabies vaccines available that are both safe and effective. Vaccines are just a part of our business at Merial. 5 dose, 10ml vial. Recombitek® offers a complete line of canine vaccines against distemper, major circulating strains CPV-2a, 2b, 2c, prevention of disease and shedding against leptospirosis. PRECAUTIONS: Store at 2-7°C (35-45°F). Merial vaccines - for quality and safety you can rely on. Contains sucrose, sodium citrate, sodium phosphate monobasic monohydrate, sodium hydroxide, polysorbate 80, cell culture media, fetal bovine serum, vero cells [DNA from porcine circoviruses (PCV) 1 … Rabies (RabAvert) February 28, 2019 admin 0. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Vaccine Ingredients What vaccines are made of. Company: Merial Rabies Vaccine. View Product Compilation Summary (Français) Search Again. PUREVAX vaccines deliver a robust, effective immune response without the need for adjuvants. As with any rabies vaccine, vaccination with RabAvert may not protect 100% of susceptible individuals. Learn more about vaccine safety. PUREVAX ® is the only fully adjuvant-free feline vaccine range and provides:. Boehringer Ingelheim will donate 75,000 doses of rabies vaccine to the Global Alliance for Rabies Control (GARC) in recognition of World Rabies Day on 28 September. The Imovax ® Rabies Vaccine produced by Sanofi Pasteur SA is a sterile, stable, freeze-dried suspension of rabies virus prepared from strain PM-1503-3M obtained from the Wistar Institute, Philadelphia, PA.. IMRAB Plus Large Animal Rabies Vaccine, 20mL, Distributor Ship. Without vaccines, the world would have lost more sons, daughters, moms and grandpas – more future teachers, builders, doctors and inventors – more people than an entire country the size of the U.S. We comply with the HONcode standard for trustworthy health information -, Direction and dosage information for IMRAB 3. Vaccines are one of the greatest public health success stories in history. Inject 1 mL subcutaneously into healthy ferrets. Merial Brands There's more to Merial than vaccines. DESCRIPTION: IMRAB ® 3 contains the same virus strain that is used in the Pasteur Merieux Connaught human vaccine. Related Pages. PUREVAX vaccines for Cats. Unit of Measure 10 Dose. Vaccine–associated adverse events were limited to mild to moderate local and systemic post-injection reactions. In rare instances, administration of vaccines may cause lethargy, fever, and inflammatory or hypersensitivity types of reactions. IMRAB rabies vaccines. Physicians must evaluate each possible rabies exposure.Local or state public health officials should be consulted if questions arise aboutthe need for prophylaxis.11 The following factors should be considered beforeantirabies prophylaxis is initiated. Poultry. PRECAUTIONS: Store at 2-7°C (35-45°F). PUREVAX vaccines for Cats. Available for Android and iOS devices. A few companies are making Thimerosal-free canine rabies vaccines. A regimen of four 1-mL doses of HDCV or PCEC vaccines should be administered intramuscularly to previously unvaccinated persons. Keep this leaflet. Rabies vaccine should never be administered in the gluteal muscle due to variable immune response. DESCRIPTION: IMRAB ® 3 TF contains the same virus strain that is used in the Pasteur Merieux Connaught human vaccine. While IM administration of pre-exposure rabies vaccine is the gold standard, the WHO considers the ID regimen an acceptable alternative, as it uses less vaccine to produce a comparable degree of protection against rabies. Rabies 3 Year. February 28, 2019 admin 0. Available for Android and iOS devices. Use entire contents when first opened. The rabies vaccine is only indicated for intramuscular administration; do not give via intravenous administration, intraarterial administration, or subcutaneous administration.

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